Protein Details: Calcium release-activated calcium channel protein 1

Protein ID

ICDB_Pro_1751

Protein Name

Calcium release-activated calcium channel protein 1

Gene Name

Orai CRACM1 olf186-F CG11430

Organism

Drosophila melanogaster (Fruit fly)

Length

351 amino acids

AlphaFoldDB

AF-Q9U6B8-F1-model_v4.pdb

Function

Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles in hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor Stim, a process known as store-operated Ca(2+) entry (SOCE). Regulates transcription factor NFAT nuclear import.

Sequence

MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQFQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFPPPPPPSSQNQAKPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQDHLEHHNNIRNNGMNYGASGDIV

PDB Structures

4HKR 4HKS 6AKI 6BBF 6BBG 6BBH 6BBI 7KR5

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1073/pnas.0603161103; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1038/nature04702; 10.1038/nature05122; 10.1126/science.1127883; 10.1126/science.1228757

RefSeq

NP_001137696.1 [Q9U6B8-3]; NP_001261063.1 [Q9U6B8-3]; NP_611273.1 [Q9U6B8-1]; NP_725727.1 [Q9U6B8-1]; NP_995881.2 [Q9U6B8-1]